Melatonin protects the liver and erythrocytes against oxidative stress in cirrhotic rats
CONCLUSION: The data allow us to suggest that the observed oxidative stress is related to the damages caused by carbon tetrachloride and that the use of melatonin can minimize these damagesCONTEXTO: A cirrose é uma hepatopatia crônica e progressiva que constitui estágio irreversÃvel de disfunção hepática. É associada a alterações na circulação sistêmica. OBJETIVOS: Avaliar o estresse oxidativo no sangue de ratos cirróticos e tratados com antioxidante melatonina. MÉTODOS: A cirrose foi induzida através da inalação de tetracloreto de carbono. Foram avaliadas as provas de integridade hepática através das medidas das enzimas séricas, o dano oxidativo medido pela lipoperoxidação e a atividade das enzimas antioxidantes no eritrócito. No fÃgado desses animais, foram avali…
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Effects of the Melatonin MT-1/MT-2 Agonist Ramelteon on Daytime Body Temperature and Sleep
Conclusions: Ramelteon improved daytime sleep, perhaps mechanistically in part by reducing core temperature and modulating skin temperature. These findings suggest that ramelteon may have promise for the treatment of insomnia associated with circadian misalignment due to circadian sleep disorders.
Keywords: Ramelteon, body temperature, melatonin agonist, daytime sleep, thermoregulation (Source: Sleep)
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Endogenous Melatonin is Not Obligatory for the Regulation of the Rat Sleep-Wake Cycle
Conclusions: Our data provide no evidence that endogenous circulating melatonin plays a role in regulating the sleep-wake cycle in rats. However, because cortical theta oscillations are generated in the CA1-3 layer of the hippocampus, neurons known to express melatonin receptors, this suggests that a lack of melatonin following pineal removal influences the function of these neurons and is consistent with previous work suggesting that endogenous melatonin is an important regulator of hippocampal physiology.
Keywords: Pinealectomy, sleep, rat, radiotelemetry, melatonin (Source: Sleep)
Acute increase in urinary 6-sulfatoximelatonin after clomipramine, as a predictive measure for emotional improvement
In this study, we compared the excretion of aMT6s before (baseline), one, and 21 days after administration of clomipramine to healthy subjects (n = 32). At the end of treatment, subjects were divided into responders (n = 12) and non-responders (n = 20) according to the improvement in their emotional state in three out of four domains (interpersonal tolerance, efficiency, well-being and feeling different from the usual self). There was no difference in aMT6s before clomipramine between responders and non-responders in any of the time intervals analysed (06:00—12:00, 12:00—18:00, 18:00—24:00 and 24:00—06:00 hours). At day one, but not at day 21, the fraction of aMT6s excreted during the time interval 24:00—06:00, relative to the total amount excreted by each sub…
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