natural sleep aid melatonin

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Sleep and Rhythm Consequences of a Genetically Induced Loss of Serotonin

By aid On February 28, 2010 No Comments

Conclusion: In this unique genetic paradigm, the melatonin deficiency (caused by a lack of its substrate, serotonin) may cause the ultradian sleep-wake rhythm.
Keywords: Sepiapterin reductase deficiency, hypersomnia, melatonin, ultradian sleep-wake rhythm, tetrahydrobiopterin, serotonin (Source: Sleep)

Melanoma, Vitiligo, and Uveitis

By aid On February 27, 2010 No Comments

Yea et al described a patient who underwent successful immunotherapy for metastatic cutaneous melanoma with autologous tumor-reactive tumor-infiltrating lymphocytes and developed ocular and systemic autoimmunity, including vitiligo and uveitis resembling Vogt-Koyanagi-Harada (VKH) Syndrome. The report provides clues into the pathogenesis of the VKH syndrome, and the authors’ review of the recent literature is informative. A further review of earlier work, principally by Lerner et al, puts this article in better perspective for the clinical ophthalmologist with regard to the relationship of melanoma, vitiligo, uveitis, and VKH. Dr Lerner, the discoverer of melatonin and the founding chair of Yale’s Department of Dermatology, spent 60 years studying vitiligo and convincingly demonstrated tha…

Different melatonin rhythms and sleep–wake rhythms in patients on peritoneal dialysis, daytime hemodialysis and nocturnal hemodialysis

By aid On February 26, 2010 No Comments

Abstract: Background: Little comparative data on sleep–wake rhythms in different dialysis groups exist. The aim of this study was to investigate sleep–wake parameters measured with actigraphy and sleep questionnaires as well as melatonin rhythms in automated peritoneal dialysis, conventional daytime hemodialysis and nocturnal hemodialysis patients.Methods: Conventional daytime dialysis (n=20), nocturnal hemodialysis (n=13) and automated peritoneal dialysis patients (n=6) were included in the study. Melatonin in saliva was sampled at 5 time points (21:00, 23:00, 1:00, 7:00 and 9:00h). Furthermore, actigraphy measurements and sleep questionnaires were performed. All parameters were tested by Kruskall–Wallis test (followed by post hoc Dunn test) to find significant differences (p (Sourc…

Melatonin Counteracts Alterations in Oxidative Metabolism and Cell Viability Induced by Intracellular Calcium Overload in Human Leucocytes: Changes with Age

By aid On February 24, 2010 No Comments

Abstract: Ageing is associated with an increased production of free radicals and alterations in the mechanisms of adaptation to oxidative stress. In fact, the free radical theory of ageing proposes that deleterious actions of free radicals are responsible for the functional deterioration associated with ageing. Moreover, a close relationship exists between calcium homeostasis and oxidative stress. The current work was aimed at proving that intracellular calcium overload induced by N-formyl-methionyl-leucyl-phenylalanine (FMLP) and/or thapsigargin leads to oxidative stress. We additionally examined the effect of melatonin on the levels of reactive oxygen species (ROS) and cell viability in human leucocytes collected from young (20[ndash]30-year-old) and elderly (65[ndash]75-year-old) indivi…