natural sleep aid melatonin http://naturalsleepaidmelatonin.com Tue, 09 Mar 2010 06:20:07 +0000 http://wordpress.org/?v=2.6 en The neuroscience of long-haul travel http://naturalsleepaidmelatonin.com/342/the-neuroscience-of-long-haul-travel/ http://naturalsleepaidmelatonin.com/342/the-neuroscience-of-long-haul-travel/#comments Tue, 09 Mar 2010 06:20:07 +0000 aid http://naturalsleepaidmelatonin.com/342/the-neuroscience-of-long-haul-travel/ Information And Reviews Natural Sleep Aid Melatonin Melatonin Supplements, Vitamins, Tablets.

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  2. Sleep-wake regulation and hypocretin-melatonin interaction in zebrafish [Neuroscience]
  3. Dissociation of circadian and light inhibition of melatonin release through forced desynchronization in the rat [Neuroscience]
]]> I travel a lot each year, the kind that most people get anxious about, involving 10+ hr time changes. People are often surprised at how little this affects me and I am often asked to share my techniques. So I thought I’d take some time to write out what I have learned.The truth is, on the first few long-haul trips I was exhausted and disorientated for days. Over a few years I started developing habits that made traveling long distances much easier. (Note - none of these habits involved any pharmaceutical or other kinds of drugs.) Speaking to other travelers, I began to see that many people had similar habits, which suggested that there may be something biological going on. The more I learned about the brain, the more these habits started to make sense. Here are some of the habits I use, an…

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  1. Use Common-Sense Lifestyle Tips for Longevity
  2. Sleep-wake regulation and hypocretin-melatonin interaction in zebrafish [Neuroscience]
  3. Dissociation of circadian and light inhibition of melatonin release through forced desynchronization in the rat [Neuroscience]

]]> http://naturalsleepaidmelatonin.com/342/the-neuroscience-of-long-haul-travel/feed/ Melatonin inhibits serotonin transporter activity in intestinal epithelial cells http://naturalsleepaidmelatonin.com/341/melatonin-inhibits-serotonin-transporter-activity-in-intestinal-epithelial-cells/ http://naturalsleepaidmelatonin.com/341/melatonin-inhibits-serotonin-transporter-activity-in-intestinal-epithelial-cells/#comments Fri, 05 Mar 2010 06:21:01 +0000 aid http://naturalsleepaidmelatonin.com/341/melatonin-inhibits-serotonin-transporter-activity-in-intestinal-epithelial-cells/ Information And Reviews Natural Sleep Aid Melatonin Melatonin Supplements, Vitamins, Tablets.

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  1. Melatonin reverses apoptosis through which menadione inhibits intestinal calcium absorption
  2. Adipocyte differentiation is inhibited by melatonin through the regulation of C/EBPβ transcriptional activity
  3. P4.12 Electrochemical measurements of mouse intestinal serotonin and melatonin: Effects of age and daily melatonin supplementation
]]> This study shows, for the first time, that melatonin modulates SERT activity, thus demonstrating the feedback system between melatonin and the serotoninergic system in the gastrointestinal tract. (Source: Journal of Pineal Research)

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  1. Melatonin reverses apoptosis through which menadione inhibits intestinal calcium absorption
  2. Adipocyte differentiation is inhibited by melatonin through the regulation of C/EBPβ transcriptional activity
  3. P4.12 Electrochemical measurements of mouse intestinal serotonin and melatonin: Effects of age and daily melatonin supplementation

]]> http://naturalsleepaidmelatonin.com/341/melatonin-inhibits-serotonin-transporter-activity-in-intestinal-epithelial-cells/feed/ N-terminal residues regulate proteasomal degradation of AANAT http://naturalsleepaidmelatonin.com/340/n-terminal-residues-regulate-proteasomal-degradation-of-aanat/ http://naturalsleepaidmelatonin.com/340/n-terminal-residues-regulate-proteasomal-degradation-of-aanat/#comments Fri, 05 Mar 2010 06:20:06 +0000 aid http://naturalsleepaidmelatonin.com/340/n-terminal-residues-regulate-proteasomal-degradation-of-aanat/ Information And Reviews Natural Sleep Aid Melatonin Melatonin Supplements, Vitamins, Tablets.

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  1. Melatonin suppresses tumor angiogenesis by inhibiting HIF-1α stabilization under hypoxia
  2. T.P.5.02 Melatonin prevents oxidative-stress mediated mitochondrial permeability transition and death in mouse skeletal muscle cells
  3. Circadian Stage-Dependent Inhibition of Human Breast Cancer Metabolism and Growth by the Nocturnal Melatonin Signal: Consequences of Its Disruption by Light at Night in Rats and Women
]]> Abstract: Serotonin N-acetyltransferase (AANAT) catalyzes the conversion of serotonin to N-acetylserotonin, which is the immediate precursor for formation of melatonin. Although it is known that AANAT is degraded via the proteasomal proteolysis, detailed mechanisms are not defined. In this paper, we tested the in vivo role of proteasome inhibition on AANAT activity and melatonin release and examined the amino acid residues in AANAT that contribute to the proteasome degradation. We have shown that inhibition of proteasome activities in vivo in the intact pineal gland fails to prevent the light-induced suppression of melatonin secretion. Furthermore, in cell lines stably expressing AANAT, inhibition of proteasomal proteolysis, which resulted in a large accumulation of AANAT protein, similarl…

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  1. Melatonin suppresses tumor angiogenesis by inhibiting HIF-1α stabilization under hypoxia
  2. T.P.5.02 Melatonin prevents oxidative-stress mediated mitochondrial permeability transition and death in mouse skeletal muscle cells
  3. Circadian Stage-Dependent Inhibition of Human Breast Cancer Metabolism and Growth by the Nocturnal Melatonin Signal: Consequences of Its Disruption by Light at Night in Rats and Women

]]> http://naturalsleepaidmelatonin.com/340/n-terminal-residues-regulate-proteasomal-degradation-of-aanat/feed/ Pre- and post-treatment of streptozocin administered rats with melatonin: effects on some hepatic enzymes of carbohydrate metabolism. http://naturalsleepaidmelatonin.com/339/pre-and-post-treatment-of-streptozocin-administered-rats-with-melatonin-effects-on-some-hepatic-enzymes-of-carbohydrate-metabolism/ http://naturalsleepaidmelatonin.com/339/pre-and-post-treatment-of-streptozocin-administered-rats-with-melatonin-effects-on-some-hepatic-enzymes-of-carbohydrate-metabolism/#comments Wed, 03 Mar 2010 06:20:06 +0000 aid http://naturalsleepaidmelatonin.com/339/pre-and-post-treatment-of-streptozocin-administered-rats-with-melatonin-effects-on-some-hepatic-enzymes-of-carbohydrate-metabolism/ Information And Reviews Natural Sleep Aid Melatonin Melatonin Supplements, Vitamins, Tablets.

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  1. Therapeutic Effects of Maternal Melatonin Administration on Ischemia/Reperfusion-Induced Oxidative Cerebral Damage in Neonatal Rats
  2. Antidepressant action of melatonin in the treatment of Delayed Sleep Phase Syndrome
  3. Chronic melatonin treatment and its precursor L-tryptophan improve the monoaminergic neurotransmission and related behavior in the aged rat brain
]]> CONCLUSION: Melatonin pre-treatment prevents the injurious effects of streptozocin in rats. In streptozocin induced diabetic animals, post-treatment with this antioxidant normalizes both blood and liver constituents which were ameliorated by streptozocin.
PMID: 20187663 [PubMed - in process] (Source: Archives of Iranian Medicine)

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Information And Reviews Natural Sleep Aid Melatonin Melatonin Supplements, Vitamins, Tablets.

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  1. Therapeutic Effects of Maternal Melatonin Administration on Ischemia/Reperfusion-Induced Oxidative Cerebral Damage in Neonatal Rats
  2. Antidepressant action of melatonin in the treatment of Delayed Sleep Phase Syndrome
  3. Chronic melatonin treatment and its precursor L-tryptophan improve the monoaminergic neurotransmission and related behavior in the aged rat brain

]]> http://naturalsleepaidmelatonin.com/339/pre-and-post-treatment-of-streptozocin-administered-rats-with-melatonin-effects-on-some-hepatic-enzymes-of-carbohydrate-metabolism/feed/ Sleep and Rhythm Consequences of a Genetically Induced Loss of Serotonin http://naturalsleepaidmelatonin.com/338/sleep-and-rhythm-consequences-of-a-genetically-induced-loss-of-serotonin/ http://naturalsleepaidmelatonin.com/338/sleep-and-rhythm-consequences-of-a-genetically-induced-loss-of-serotonin/#comments Sun, 28 Feb 2010 06:20:05 +0000 aid http://naturalsleepaidmelatonin.com/338/sleep-and-rhythm-consequences-of-a-genetically-induced-loss-of-serotonin/ Information And Reviews Natural Sleep Aid Melatonin Melatonin Supplements, Vitamins, Tablets.

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  1. Effect of melatonin on age induced changes in daily serotonin rhythms in suprachiasmatic nucleus of male Wistar rat.
  2. Sleep-wake regulation and hypocretin-melatonin interaction in zebrafish [Neuroscience]
  3. Impairment of endogenous melatonin rhythm is related to the degree of chronic kidney disease (CREAM study)
]]> Conclusion: In this unique genetic paradigm, the melatonin deficiency (caused by a lack of its substrate, serotonin) may cause the ultradian sleep-wake rhythm.
Keywords: Sepiapterin reductase deficiency, hypersomnia, melatonin, ultradian sleep-wake rhythm, tetrahydrobiopterin, serotonin (Source: Sleep)

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  1. Effect of melatonin on age induced changes in daily serotonin rhythms in suprachiasmatic nucleus of male Wistar rat.
  2. Sleep-wake regulation and hypocretin-melatonin interaction in zebrafish [Neuroscience]
  3. Impairment of endogenous melatonin rhythm is related to the degree of chronic kidney disease (CREAM study)

]]> http://naturalsleepaidmelatonin.com/338/sleep-and-rhythm-consequences-of-a-genetically-induced-loss-of-serotonin/feed/ Melanoma, Vitiligo, and Uveitis http://naturalsleepaidmelatonin.com/337/melanoma-vitiligo-and-uveitis/ http://naturalsleepaidmelatonin.com/337/melanoma-vitiligo-and-uveitis/#comments Sat, 27 Feb 2010 06:20:40 +0000 aid http://naturalsleepaidmelatonin.com/337/melanoma-vitiligo-and-uveitis/ Information And Reviews Natural Sleep Aid Melatonin Melatonin Supplements, Vitamins, Tablets.

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]]> Yea et al described a patient who underwent successful immunotherapy for metastatic cutaneous melanoma with autologous tumor-reactive tumor-infiltrating lymphocytes and developed ocular and systemic autoimmunity, including vitiligo and uveitis resembling Vogt-Koyanagi-Harada (VKH) Syndrome. The report provides clues into the pathogenesis of the VKH syndrome, and the authors’ review of the recent literature is informative. A further review of earlier work, principally by Lerner et al, puts this article in better perspective for the clinical ophthalmologist with regard to the relationship of melanoma, vitiligo, uveitis, and VKH. Dr Lerner, the discoverer of melatonin and the founding chair of Yale’s Department of Dermatology, spent 60 years studying vitiligo and convincingly demonstrated tha…

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]]> http://naturalsleepaidmelatonin.com/337/melanoma-vitiligo-and-uveitis/feed/ Different melatonin rhythms and sleep–wake rhythms in patients on peritoneal dialysis, daytime hemodialysis and nocturnal hemodialysis http://naturalsleepaidmelatonin.com/336/different-melatonin-rhythms-and-sleep%e2%80%93wake-rhythms-in-patients-on-peritoneal-dialysis-daytime-hemodialysis-and-nocturnal-hemodialysis/ http://naturalsleepaidmelatonin.com/336/different-melatonin-rhythms-and-sleep%e2%80%93wake-rhythms-in-patients-on-peritoneal-dialysis-daytime-hemodialysis-and-nocturnal-hemodialysis/#comments Fri, 26 Feb 2010 06:20:05 +0000 aid http://naturalsleepaidmelatonin.com/336/different-melatonin-rhythms-and-sleep%e2%80%93wake-rhythms-in-patients-on-peritoneal-dialysis-daytime-hemodialysis-and-nocturnal-hemodialysis/ Information And Reviews Natural Sleep Aid Melatonin Melatonin Supplements, Vitamins, Tablets.

Related posts:
  1. Sleep-wake regulation and hypocretin-melatonin interaction in zebrafish [Neuroscience]
  2. Melatonin decreases daytime challenging behaviour in persons with intellectual disability and chronic insomnia
  3. Impairment of endogenous melatonin rhythm is related to the degree of chronic kidney disease (CREAM study)
]]> Abstract: Background: Little comparative data on sleep–wake rhythms in different dialysis groups exist. The aim of this study was to investigate sleep–wake parameters measured with actigraphy and sleep questionnaires as well as melatonin rhythms in automated peritoneal dialysis, conventional daytime hemodialysis and nocturnal hemodialysis patients.Methods: Conventional daytime dialysis (n=20), nocturnal hemodialysis (n=13) and automated peritoneal dialysis patients (n=6) were included in the study. Melatonin in saliva was sampled at 5 time points (21:00, 23:00, 1:00, 7:00 and 9:00h). Furthermore, actigraphy measurements and sleep questionnaires were performed. All parameters were tested by Kruskall–Wallis test (followed by post hoc Dunn test) to find significant differences (p (Sourc…

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  1. Sleep-wake regulation and hypocretin-melatonin interaction in zebrafish [Neuroscience]
  2. Melatonin decreases daytime challenging behaviour in persons with intellectual disability and chronic insomnia
  3. Impairment of endogenous melatonin rhythm is related to the degree of chronic kidney disease (CREAM study)

]]> http://naturalsleepaidmelatonin.com/336/different-melatonin-rhythms-and-sleep%e2%80%93wake-rhythms-in-patients-on-peritoneal-dialysis-daytime-hemodialysis-and-nocturnal-hemodialysis/feed/ Melatonin Counteracts Alterations in Oxidative Metabolism and Cell Viability Induced by Intracellular Calcium Overload in Human Leucocytes: Changes with Age http://naturalsleepaidmelatonin.com/335/melatonin-counteracts-alterations-in-oxidative-metabolism-and-cell-viability-induced-by-intracellular-calcium-overload-in-human-leucocytes-changes-with-age/ http://naturalsleepaidmelatonin.com/335/melatonin-counteracts-alterations-in-oxidative-metabolism-and-cell-viability-induced-by-intracellular-calcium-overload-in-human-leucocytes-changes-with-age/#comments Wed, 24 Feb 2010 06:21:01 +0000 aid http://naturalsleepaidmelatonin.com/335/melatonin-counteracts-alterations-in-oxidative-metabolism-and-cell-viability-induced-by-intracellular-calcium-overload-in-human-leucocytes-changes-with-age/ Information And Reviews Natural Sleep Aid Melatonin Melatonin Supplements, Vitamins, Tablets.

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  3. Effect of melatonin on burn-induced gastric mucosal injury in rats
]]> Abstract: Ageing is associated with an increased production of free radicals and alterations in the mechanisms of adaptation to oxidative stress. In fact, the free radical theory of ageing proposes that deleterious actions of free radicals are responsible for the functional deterioration associated with ageing. Moreover, a close relationship exists between calcium homeostasis and oxidative stress. The current work was aimed at proving that intracellular calcium overload induced by N-formyl-methionyl-leucyl-phenylalanine (FMLP) and/or thapsigargin leads to oxidative stress. We additionally examined the effect of melatonin on the levels of reactive oxygen species (ROS) and cell viability in human leucocytes collected from young (20[ndash]30-year-old) and elderly (65[ndash]75-year-old) indivi…

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  1. The ultrastructural and biochemical evidences of the beneficial effects of chronic caffeic acid phenethyl ester and melatonin administration on brain and cerebellum of aged rats
  2. Protective Effect of Melatonin Against Mitomycin C-Induced Genotoxic Damage in Peripheral Blood of Rats
  3. Effect of melatonin on burn-induced gastric mucosal injury in rats

]]> http://naturalsleepaidmelatonin.com/335/melatonin-counteracts-alterations-in-oxidative-metabolism-and-cell-viability-induced-by-intracellular-calcium-overload-in-human-leucocytes-changes-with-age/feed/