Acute increase in urinary 6-sulfatoximelatonin after clomipramine, as a predictive measure for emotional improvement

In this study, we compared the excretion of aMT6s before (baseline), one, and 21 days after administration of clomipramine to healthy subjects (n = 32). At the end of treatment, subjects were divided into responders (n = 12) and non-responders (n = 20) according to the improvement in their emotional state in three out of four domains (interpersonal tolerance, efficiency, well-being and feeling different from the usual self). There was no difference in aMT6s before clomipramine between responders and non-responders in any of the time intervals analysed (06:00—12:00, 12:00—18:00, 18:00—24:00 and 24:00—06:00 hours). At day one, but not at day 21, the fraction of aMT6s excreted during the time interval 24:00—06:00, relative to the total amount excreted by each sub…

Related posts:

1. The mechanism for the neuroprotective effect of melatonin against methamphetamine?induced autophagy
2. Insomnia treatment ‘effective for up to six months’
3. Effects of the Melatonin MT-1/MT-2 Agonist Ramelteon on Daytime Body Temperature and Sleep
4. Vanda Pharmaceuticals Initiates Phase III Clinical Study Aimed At Resetting The Body Clock
5. Ramelteon attenuates age-associated hypertension and weight gain in spontaneously hypertensive rats