Is melatonin effective for preventing cluster headache?

Source: Wessex Drug and Medicines Information Centre
Area: Evidence > Medicines Q & A
. Cluster headaches are classified as primary headaches within the group of trigeminal autonomic cephalalgias (TAC). They occur as either Episodic Cluster Headache (ECH) or Chronic Cluster Headache (CCH). The excruciating pain suffered during attacks, causes a poor quality of life.
 
. CH tends to be seasonal. Attacks may also occur at the same time each day and about two-thirds of patients suffer CH during sleep.
 
. The naturally occurring hormone melatonin is associated with the control of circadian rhythms and entrainment to the light-dark cycle. Physiologically, melatonin secretion increases soon after the onset of darkness.
 
. Decreased nocturnal secr…

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