Differential effects of melatonin on amyloid-β peptide 25–35-induced mitochondrial dysfunction in hippocampal neurons at different stages of culture

Abstract: [beta]-Amyloid (A[beta]) is strongly involved in the pathogenesis of Alzheimer’s disease (AD), and mitochondria play an important role in neurodegenerative disorders. To determine whether any different effect of melatonin on cultured neurons treated with A[beta] in vitro and which may be produced through its different action on mitochondria at different stages of culture, we investigated the damage of cultured rat hippocampal neurons mitochondrial function induced by A[beta] in young neurons [days in vitro 10 (DIV 10)] and senescent neurons (DIV 25) and the protective effect of melatonin. Rat hippocampal neurons were incubated with amyloid-[beta] peptide 25[ndash]35 (A[beta]25-35) alone or pretreatment with melatonin. Cell viability, mitochondrial membrane potential ([Delta][psi]…

Related posts:

1. Amyloid-β neurotoxicity in organotypic culture is attenuated by melatonin: involvement of GSK-3β, tau and neuroinflammation
2. Visualization of melatonin’s multiple mitochondrial levels of protection against mitochondrial Ca2+-mediated permeability transition and beyond in rat brain astrocytes
3. MT2 Melatonin Receptor Immunoreactivity in Neurons is Very High in the Aged Hippocampal Formation in Gerbils.
4. Psychopharmacological Neuroprotection in Neurodegenerative Disease: Assessing the Preclinical Data [SPECIAL ARTICLES]
5. Differential Regulation of Kiss1 Expression by Melatonin and Gonadal Hormones in Male and Female Syrian Hamsters